A case of multiple myeloma (myelomatosis) with Bence-Jones proteid in the urine (myelopathic albumosuria of Bradshaw, Kahler's disease) and a summary of published cases of Bence-Jones albumosuria / by F. Parkes Weber ; with a report on the chemical pathology by R. Hutchison and J.J.R. Macleod.

  • Weber, Frederick Parkes, 1863-1962.
Date:
1903
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Licence: In copyright

Credit: A case of multiple myeloma (myelomatosis) with Bence-Jones proteid in the urine (myelopathic albumosuria of Bradshaw, Kahler's disease) and a summary of published cases of Bence-Jones albumosuria / by F. Parkes Weber ; with a report on the chemical pathology by R. Hutchison and J.J.R. Macleod. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Jones proteid 1 in the patient’s urine had been frequently, at one time daily, measured by Esbach’s albuminimeter, but had been entered in the notes as ordinary albumen. The daily amount of urine was found to be about 2000 c.c., and it contained about 7 per mille of the proteid. The reactions, as afterwards ascertained, were quite typical, just as those described by Bradshaw, Ktilme, Bence-Jones, and others. The most characteristic are, I think, the following (that is, when the urine is acid2) :—Coagulation of the proteid at a much lower temperature (about 58° C.) than ordinary albumen, more or less solution of the precipitate at a higher temperature (e. g. when the urine is boiled), and complete or almost complete solution on adding acetic acid to the boiling urine ; after the precipitate has been partially re-dissolved by boiling, a characteristic re-precipitation should take place on allowing the urine to cool. What Dr. Bradshaw considered to be the spon- taneous precipitation of the proteid in his case (noted also in some other cases) was likewise observed in the urine of the present case. The urine sometimes was turbid with this precipitate when quite freshly passed, and on these occasions, the reaction being always very acid, the turbidity could not be due to phosphates. Exact details in regard to the urine are contained in the following history of the case, which includes reports on the urine by Dr. R. Hutchison. 1 On account of the contention by A. Magnus-Levy (Hoppe-Seyler’s ‘ Zeit. f. phys. Chemie,’ Strassburg, 1900, vol. xxx, p. 200) that the so-called Bence-Jones albumose is really an albumen, I have referred to it in this paper as Bence-Jones proteid. For the sake of brevity, how- ever, I have sometimes spoken of “ Bence-Jones albumosuria,” when I meant to signify the presence of Bence-Jones proteid in the urine. It seems that precipitin experiments fail to solve this question of the nature of the Bence-Jones proteid. In fact, the so-called “ biological method” fails to distinguish the Bence-Jones proteid from various other proteids of human origin (ride Bostoski, “ Zur Kenntniss der Pracipi- tine,” ‘ Verhandl. der Phys.-med. Gesellsehaft, Wurzburg/ 1902, vol. xxxv, pp. 30—32).