New pharmaceutical compound of gelatin and tannin.

  • Aktiengesellschaft für Anilinfabrikation.
Date:
1899
Catalogue details

Licence: Public Domain Mark

Credit: New pharmaceutical compound of gelatin and tannin. Source: Wellcome Collection.

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    5 10 15 20 25 30 35 40 N° 11,001 Date of Application, 14th May, 1898 Complete Specification Left, 14th Feb., 1399 —Accepted, 18th Mar., 1899 PROVISIONAL SPECIFICATION. New Pharmaceutical Compound of Gelatin and Tannin. I, Charles Denton Abel, of Birkbeck Bank Chambers, Southampton Buildings, in the County of London, Consulting Engineer and Chartered Patent Agent, do hereby declare the nature of this invention (as communicated to me from abroad by The Actien-Gesellschaft fur Anilin-Fabrikation, of Berlin, in the German Empire, Chemical Manufacturers) to be as follows; — It is well known that the compound of gelatin and tannin is putrescible while the corresponding compounds derived from other tannic acids are not. My foreign correspondents have now discovered that this property is essentially caused by the water retained by the raw precipitate obtained from solutions of gelatin and tannin. Consequently if this' water is removed by heating the precipitate up to 100° C. or even for a short time at more elevated temperatures a stable and non-putrescible product is obtained), which can therefore be used for medicinal purposes. My foreign correspondents have discovered that it may be applied as an astrin¬ gent acting only in the intestines, as it is insoluble or hardly soluble in the juices of the stomach while it is attacked by the alkaline juices of the intestines. There is however, another difficulty in obtaining this gelatin tannate in a form proper for medicinal purposes. As the gelatin tannin precipitate even after the mother lyes having been removed by pressure retains large quantities of water, it melts at relatively low temperature, a viscous and leatherlike mass being formed which it is very difficult to dry completely and to pulverize. By heating the same for a long time on the water bath it is possible to remove the water, but the product obtained in this way is not only strongly coloured but decomposes much more readily than pure gelatin tannate, and assumes a disagreeable taste and smell when heated above 100° C. (for instance in order to sterilize it or to render it even more resistant to the stomach juices). These inconveniences are specially experienced if larger quantities of gelatin- tannate are dealt with in one operation. Now my foreign correspondents have discovered that the melting of the raw precipitate may be avoided by allowing the latter to lie in the open air and at ordinary temperature for about 24 hours. Thereby nearly all water is removed and the remaining powder may be completely dried on the water bath without melting. In order to remove the last traces of water it is advisable to dry finally at higher temperatures not exceeding 150° C. The product thus obtained may be pulverized without any difficulty. It is almost colourless and has no taste or smell. Thus it is completely fit for medicinal purposes. Dated this 14th day of May 1898. \Priee 8d.] ABEL & IMRAY, Agents for the' Applicant.