Studies in isoagglutination. III. Tonicity in isohemagglutination / by Morris H. Kahn and Reuben Ottenberg.

  • Kahn, Morris H.
Date:
[1911]
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Credit: Studies in isoagglutination. III. Tonicity in isohemagglutination / by Morris H. Kahn and Reuben Ottenberg. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    [Reprinted from the Journal of Experimental Medicine, Vol. XIII, No. 5. 191U STUDIES IN ISOAGGLUTINATION. III. TONICITY IN ISOHEMAGGLUTINATION.* By MORRIS H. KAHN and REUBEN OTTENBERG. (From the Pathological Laboratory of Mount Sinai Hospital and the Labora- tory of Biological Chemistry of Columbia University, at the College of Physicians and Surgeons, New York.) • In the introduction to the first paper in the present series,1 an outline was given of the main facts concerning the isoagglutination of human bloods, and the division of human bloods into four sharply defined varieties or groups, according to the way in which they agglutinate each other. For the present purpose these groups may be briefly summarized as follows: In group I the serum aggluti- nates the cells of all other groups, but the cells are not agglutinable. In group II the serum agglutinates the cells of groups III and IV, and the cells are agglutinable by the sera of groups I and III. In group III the serum agglutinates the cells of groups II and IV, and the cells are agglutinable by sera of groups I and II. In group IV the serum is non-agglutinative, and the cells are agglutinable by seia of all other groups. Three years ago Gay attempted to show that a relation existed between the resistance of human red blood cells to laking by hypo- tonic solutions and their isoagglutinative grouping. In an exami- nation of twelve bloods he found that corpuscles not agglutinated by any sera (i. e., those belonging to group I) are more susceptible to laking by saline solutions of low percentage content than are * Received for publication, March 17, K>n. This study is one of a projected series on isoagglutination, which in turn constitutes a section of a comprehensive plan of research on the composition of protoplasm, as well as the structural and dynamic relationships of cell constituents and products. These investigations are now in progress in the Laboratory of Biological Chemistry of Columbia Uni- versity, at the College of Physicians and Surgeons, and under the auspices of the George Crocker Special Research Fund. 1 Ottenberg, Jour. Exper. Med., 1911, xiii, 425-