A manual of hypodermatic medication : the treatment of diseases by the hypodermatic method. / by Roberts Bartholow.

Date:
1882
Catalogue details

Licence: Public Domain Mark

Credit: A manual of hypodermatic medication : the treatment of diseases by the hypodermatic method. / by Roberts Bartholow. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    and Dr. Lorent* are equally unmindful of Kur- zak’s claim to be recognized as# the discoverer of hypodermatic medication. How far, if at all, the progress of physiolog- ical research influenced the endermic and sub- dermic application of remedies cannot now be stated with precision; nevertheless there are some important facts which have a distinct relation to the subject under consideration. The first re- search into the action of a medicament made by the physiological method was conducted by Ma- gendie, about 1819, upon the upas and nux vomica, and on strychnia. In the course of this research Magendie first demonstrated that poisons acted by absorption into the blood. To ascertain the general effects of the remedy being examined, he introduced some of it * under the skin of the thigh, and then observed the actions as they occurred. This experiment was performed in 1819.f In the course of this research, also, he tested the rate of absorption from different parts, including the veins. Subsequently, Bernard, pursuing his investigations into the action of curara, and also in his studies of the poisons, introduced the med- icament, the subject of experiment, under the skin. I It was, therefore, perfectly well known * Die hypoderm. Inject, nach clinischen Erfahrungen. Leipzig, 1805, p. 1. f Ann. de Ohitn. et de Physiol., vol. xvi., 1819. t Le(jons sur les Eft’ets des Substances toxiques et niediea- menteuses. Paris, 1857, p. 272.