Pesticides in the diets of infants and children / Committee on Pesticides in the Diets of Infants and Children, Board on Agriculture and Board on Environmental Studies and Toxicology, Commission on Life Science, National Research Council.

Washington, D.C. : National Academy Press, 1993.

xv, 386 pages : illustrations ; 23 cm

Includes bibliographical references and index

Background and approach to the study -- Pesticide use -- Pesticide control legislation -- Approach to the study -- Special characteristics of children -- Growth -- Development -- Perinatal and pediatric toxicity -- Acute toxicity -- Neurotoxicity -- Immunotoxicity -- Carcinogenesis and mutagenesis -- Metabolism and pharmacokinetics -- Scaling and progression analysis -- Methods for toxicity testing -- Current methods: general considerations -- Acute toxicity studies -- Subchronic toxicity studies -- Chronic toxicity studies -- Developmental toxicity studies -- Reproduction studies -- Mutagenicity studies -- General metabolism studies -- Neurotoxicity studies -- Special testing -- Food and water consumption -- Food consumption surveys -- Survey methodology -- Survey design -- Sample weights -- Sample size -- Comparisons of intake data with standards -- Validation of food consumption data -- Strengths and weaknesses of the food consumption data bases in estimating pesticide exposure of children -- Water intake -- Quantification of consumption data -- Age-related differences in dietary patterns

(cont) Issues related to the evaluation of food monitoring data -- Pesticide residues -- Sources of data on usage -- Ocurrence and fate of pesticide residues -- Pesticide registration and the development of analytical methods -- Methods for sampling and analysis -- Monitoring -- Quality controls -- Limitations of the data -- Pesticides in water -- Pesticides in infant formula -- Pesticides in human milk -- Pesticides in foods -- Estimating exposures -- Use of food consumption and residue data for exposure assessment -- Long-term exposure to benomyl -- Short-term exposure to aldicarb -- Multiple exposure assessment: organophosphate insecticides -- Nondietary exposure to pesticides -- Estimating the risks -- General principles of risk assessment -- Risk assessments for infants and children.