Genetic studies in mental subnormality.

Date:
1973
Catalogue details

Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Genetic studies in mental subnormality. Source: Wellcome Collection.

    10/100 (page VI)
    page References ............. 2] Appendices I and II Appendix I Appendix II Appendix III Pedigrees Histories and Case Summaries of Families Where Two or More Members were Severely Subnormal or Borderline Subnormal/ Severely Subnormal ........ 29 30 families where the underlying cause of severe subnormality was known in all or all but one member . . . . . . . 29 141 families where the underlying cause of severe subnormality was not known in two or more affected members . . . . .32 A. 50 families where only males were severely subnormal or borderline subnormal/severely subnormal ...... 32 B. 21 families where only females were severely subnormal or borderline subnormal/severely subnormal ...... 36 C. 70 families where males and females were severely subnormal or borderline subnormal/severely subnormal . . . . 38 Implications of the Findings—Giving Genetic Advice . 45 • . 45-60 PART II THE APPLICATION OF GENETIC PRINCIPLES TO SCREENING FOR METABOLIC DISORDERS The Leybourne Grange Survey of Mentally Subnormal Siblings By PETER N. SWIFT, PHILIP F. BENSON and JOHN D. STUDDY I Introduction ........... 61 II The Procedure of the Investigation. Family and Personal History. 62 III Results. Classification of Data ....... 63 IV Group D : Families in which Siblings have Similar Clinical Abnor¬ mality but no Biochemical Disorder ..... 64 Case Reports 65, V Group E: Families in which Siblings have Similar Biochemical Disorders .......... 7^ Case Reports 7^ VI General Discussion . . . . . . . . 75 VII Summary . . . . . • • • . . . 7® References . . . . . . • • -79 Appendix Group A : Families with a Previously Described Disorder ... 80 Group В ; Families with Unclassified Disorders . . . . .80 Group C: Families in which Siblings had no Similar Clinical Features or Biochemical Abnormality ... . . . • • • 81