On the alterations in the red globules in malaria infection, and on the origin of melanæmia : memoir / by Ettore Marchiafava and A. Celli ; translated and edited by Edward Drummond.

  • Marchiafava, Ettore, 1847-1935.
Date:
1888
Catalogue details

Licence: Public Domain Mark

Credit: On the alterations in the red globules in malaria infection, and on the origin of melanæmia : memoir / by Ettore Marchiafava and A. Celli ; translated and edited by Edward Drummond. Source: Wellcome Collection.

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    essential part of their humoral pathology, and Galen held that it accumulated in thè spleen and caused engorgcment of thè blood vessels, destruction of thè intestines, and serious disturbances of thè nervous System. Leaving on one side, however, thè views of thè ancients about “black bile,” we find that from thè last century it began to he noticed that some orgaus showed a black or blackish colour in grave malarious fevers, so that Lancisi,* for cxample, speaking of thè changes met witli in persons dead from malaria, says : Primum in iis qui ob tcrtianos perniciosas occiderunt, ingens malorum sedes sub aspectum venit in abdomine ubi omnia livida, et potissimum hepar subfusci, ac bilis cgstica tri coloni passim occurrerunt. Mekel, however, was thè first to observe pigment in thè blood, and held that it passed from thè spleen into thè blood. Yirchowf discovered pigmented elements in thè blood and spleen of a man who died of dropsy following repeat-ed attacks of malarious fever. Ile believed thè pigment to be derived from thè spleen, and pcrsisted in affirming melamemia to be a dyscrasia of that organ. Tigri saw and described melanosis of thè spleen as “ black spleen.” Frerichs X accurately described melamemia and its effects. He observed black granules, pigment cells, masses of black granules held together by liyalinc substance, delicate of dense, but always without fixed shape, and pigment masses, sometimes cyliudrical with parallel facets, surrounded by a ring of pellucid substance. He believed thè pigment formed in thè spleen, and passed into thè generai circulation. In proof of this he adduced thè following arguments :— . a. Pigment is found in thè healthy spleen, b. In melamemia thè spleen is always more largely charged with pigment. c. Pigmented epithelium of thè spleen is found in thè generai circulation. He believed that thè liver shared in this power of forming pig- ment. He confirmed thè view of Virchow that in intermittents pigment forms in thè spleen and passes into thè circulation. Colin § holds, on thè other band, that this formation is not * De noxiis paludum ejìuviis eorumque remediis. Roma, 1 < 27. | Cellular Pathology. Berlin, 1881. j Loc. cit. § Traiti detjtèvrei intermittente). Paris, 1870.