Chemistry of mucus. Part 2, The composition of glycoproteins from gastrointestinal carcinoma.

UK : University of London, 1975.

1 encoded moving image (20 min.) : sound, black and white.

00:20:23

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr. J. Schrager, Area Consultant Pathologist, Royal Albert Edward Infirmary, Wigan. Produced by David R. Clark.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Opening credits. Dr Schrager summarises Part 1 of the lecture and says that in Part 2 he will report a comparative study of glycoproteins isolated from stomachs containing a carcinoma. He describes the study, which used gel chromatography to elute normal mucosa and the carcinoma. A graph shows the results of the chromatography, and a chemical chart showing the glycoproteins is also seen. Time start: 00:00:00:00 Time end: 00:05:23:00 Length: 00:05:23:00

Segment 2 Next, Schrager discusses glycoproteins coming from the carcinoma. A table shows information on malignant glycoproteins, and Schrager describes their properties and structure. He also talks about their amino acid compositions. Time start: 00:05:23:00 Time end: 00:09:44:05 Length: 00:04:21:05

Segment 3 Schrager compares the composition of normal and malignant glycoproteins, saying that there is a fundamental similarity. A table lists their carbohydrate abundances. He discusses the enzymes present in the two glycoproteins. Time start: 00:09:44:05 Time end: 00:15:44:00 Length: 00:05:59:20

Segment 4 Schrager discusses the stability of the malignant glycoproteins. He goes on to talk about how the results of this study provide a new approach to the classification of carcinomata of the gastrointestinal tract. Tables list figures relating to malignant glycoproteins. Schrager discusses how to classify them according to secretion, sialic acid content and sulfation. Time start: 00:15:44:00 Time end: 00:20:23:18 Length: 00:04:39:18