A preliminary report on 120 cases of tuberculosis treated with the Friedmann vaccine / by Harry Lee Barnes.

  • Barnes, Harry Lee, 1877-
Date:
1913
Catalogue details

Licence: In copyright

Credit: A preliminary report on 120 cases of tuberculosis treated with the Friedmann vaccine / by Harry Lee Barnes. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    For past week has had much frequency and pain over bladder; urine is very cloudy and irrigation returns bloody; only boric acid sol. used; has had Friedmann vaccine again; bladder will hold only small amount and is too irritable for use of cystoscope. August 2o. Bladder holds only a little over 3 oz. to-day; urine is quite cloudy, mere now than at last visit; cystoscope shows condition of bladder about the same as on May 22. September 1. Patient has evidently made some improvement during the past five months as evidenced by the absence of blood and reduced amount of pus. Whether this improvement has resulted from the rest and open air life or from the vaccine it is impossible to say. Her symptoms improved as much while here during 1909. Numerous tubercle bacilli and pus cells were found in the urine on August 27th, and tubercle bacilli have recently been found in the sputum. Centrifugalized sediment from the urine of this patient was injected into the peritoneal cavity of a guinea pig on July 9th, and the animal was killed on August 26th. Sections of liver, omentum and spleen made by Dr. Sawyer showed tuber- culosis. A control animal remained healthy and was found free from tuberculosis at autopsy. Case No. 2019. H. F. Male, age 27, admitted February 17, 1913. Duration 132 months. Left upper lobe has dullness, suppressed breath- ing and deep subcrepitant rales over the left upper lobe front and back. Increased frequency of urination but no pain. Pus 200 cells to high power field; numerous tubercle bacilli found. March 28. Subcrepi- tant rales and suppressed breathing heard over left back to mid-scapular region and to lower angle of right scapular region. April 9th. Patient has gained six pounds in weight. Frequency of micturition has dimin- ished. Patient has to get up only two or three times at night instead of four as when admitted. First injection of vaccine to-day. May 8th. Mic- turition only once a night during past week. Induration lasted only a few days. May 28th. Second injection of vaccine. June 11th. Pa- tient had a fever reaction and vomiting after last dose of vaccine. Has an induration. Micturition once or twice at night and seven times daily. Average capacity of bladder 210 c. c. August 26th. Micturi- tion seven times daily and twice at night, rarely once. Rales have diminished in both lungs. Patient’s frequency of micturition had begun to diminish before he took the vaccine, and has not improved much since. The urine contains pus and tubercle bacilli. On July 9, sediment from the urine of this patient was injected into the peritoneal cavity of a guinea pig, and no tuberculosis could be found in this animal when killed on August 26th. Class C. Failed Before and After the Vaccine Treatment. Case No. 1853. E. F., Female, age 19, admitted July 22, 1912. An incipient case as far as the lungs were concerned, having only slight dullness, harsh breathing and a very few fine rales at the right apex. For a ear and a half patient has had tuberculous adenitis, the cervical glands in both sides of the neck and in the left axillary region being affected.