A report of microscopical and physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham.

  • Lewis, T. R. (Timothy Richards), 1841-1886.
Date:
1872
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Licence: Public Domain Mark

Credit: A report of microscopical and physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham. Source: Wellcome Collection.

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    producing any marked result, was again placed under chloroform and half an ounce of the decomposing solution of ordinary foecal matter (exactly as used in the last experiment (LIV), both experiments being performed on the same day) was injected into the median basilic vein. After the operation, it is noted, the dog appears as if No result; killedimder nothing had happened. He was chloroform after a week. j^gp^ uudcr observatiou for a wcck, when, in order to ascertain what changes all these putrefying matters might have produced, he was again placed under chloroform, and allowed to breathe it till respiration ceased. The wounds over two of the three veins which had been tied were completely healed. There was no peritonitis, the Hepatized tissue in both ^testines wcrc pale and perfectly l^faVasated'& % °t^e' J^ealthy, SO wcrc all the viscera except biood^' ^^ bacteria ta the the luugs and splccn. In the former, on both sides, large patches of hepatiz- ed tissue were found evidently due to pneumonia, and, enclosed by this altered tissue, at one spot was a small cavity filled with a dark thickish fluid. In the spleen there was, near the sur- face of one end, a smaU extravasated pouch about the size of a hazel-nut. The blood was carefully examined for monads and bacteria, but none could be found. Experiment LVI.—Half an ounce of a decomposing Material used; solution of solutiou of Ordinary alviuo discharge, oldfno'^S^^' 72 hours old, the same as used in . ^ ^, . , Experiment XLVII, &c., was injected into the right femoral vein of a dog, previously brought under the influence of chloroform. Not a drop of blood was lost during the operation. ^ There were not the sHghtest manifestations of illness during the three days the animal was kept under observation, and when the viscera were examined after it had been kiUed under chloroform, they were all found to be perfectly V * A wax-cell preparation of the blood was kept under ■D ^ . . ^ observation for three davs, but no Bacteria not developed in • J''^> --^ the blood, nor in the glands. Dactcria uor any othcr oro-auisms , , . developed. A similar preparation was made by squeezing some fluid out of a mesenteric gland • here also no monads or bacteria could be detected during the period above named. ^