The harmful effects of acetanilid, antipyrin, and phenacetin / By L.F. Kebler ... with the collaboration of Drs. F.P. Morgan and Philip Rupp.

  • Kebler, Lyman F. (Lyman Frederic), 1863-
Date:
1909
Catalogue details

Licence: Public Domain Mark

Credit: The harmful effects of acetanilid, antipyrin, and phenacetin / By L.F. Kebler ... with the collaboration of Drs. F.P. Morgan and Philip Rupp. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

    15/98 (page 9)
    REPORTS OF PHYSICIANS WITH REGARD TO PERSONAL EXPERI- ENCE IN THE USE OF ACETANILID, ANTIPYRIN, AND ACET- PHENETIDIN (PHENACETIN). For the purpose of obtaining information with regard to the poisonous eli'ects of acetanilid, antipyrin, and phenacetin from the viewpoint of personal experience and observation, the following letter of inquiry was addressed by the Department of Agriculture to medical practitioners in the United States: United States Department of Agriculture, Bureau of Chemistry, Washington, D. C, June 1, 1908. Dear Sir: We are collecting inforuiatiou relative to the poisonous nature of acetanilid, antipyrin, and phenacetin, and in order to make the data as com- plete as possible I am sendinij; you a number of questions and would ask that you supi)ly the information requested at your earliest convenience. If there is not sutticient space allowed to give all the data you may possess it is expected that you will use the blank pages of the folder, making the statement as concise as possible. The information requested is for the use of the Department in comi)iling a bulletin, and general cretllt will be given for all data supplied. An early reply will be much appreciated. Respectfully, H. W. Wiley, Chief. Following ar*e the questions referred to in this communication, tlie inquiries relating in each instance to the three drugs—acetanilid, antipyrin, and phenacetin: 1. To what extent do you use these drugs in your ])ractice? 2. What dose do you ordinarily i)rescribe for adultsV 3. Do you prescribe them more or less freipiently than formerly? Why? 4. What is your (»i)inion with regard to the relative safety of these three drugsV f). Have you observed instances of acute or chronic poisoning or cyanosis caused by these drugs? How many of each? 0. In what form was the drug administered? 7. About what dates did tiie poisoning occur? 5. Were the patients adults or children? 1>. For what ailment was the drug taken? 10. Was it ordered by a physician? 11. Was it used internally or externally? 12. Quantity taken? I.'J. Give brief history of cases observed by you, omitting details. 14. Have you ol).served any cases of habitual use of any of these drugs or of any jtrepiirations containing them? I.'J. In what form was the drug taken? 16. Were there any ill effects? (Jive? brief description. 17. Were there any protracted ill efl'e<ts? 18. Give a brief clinical liistory of each case. This lettci' of inquiry was sent (o physicians (Inoughoiil the Fuitcd ►States, (he oljject bcurig to secure inroiinalion which woiihl represent