Diabetes, mellitus and insipidus / by Andrew H. Smith.

  • Smith Andrew H. (Andrew Heermance), 1837-1910.
Date:
1889
Catalogue details

Licence: Public Domain Mark

Credit: Diabetes, mellitus and insipidus / by Andrew H. Smith. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    longed hypersemia. The capillaries are dilated and distended with blood. The acini are enlarged. The liver-cells are increased in size, their angles rounded off, and the margins indistinct. 'The nuclei are sharply defined. A wine color is developed by the application of tincture of iodine, which, according to Klebs, is due to a post-mortem change in the gly- cogen. The kidneys in cases of short duration are not involved; but the functional activity implied in long continued polyuria, eventually leads to hyperaemia with corresponding changes in the renal structure, d'here is a proliferation of the epithelium which in- creases the size of the whole organ. The epithelium is prone to become detached, and a condition resem- bling desquamative nephritis may be found. In such cases albuminuria has been present during life. But little interstitial change is observed, the parenchyma, rather than the stroma, being affected. A catarrhal condition of the pelves of the kid- neys, and of the ureters, may be present, due to the irritation caused by the sugar in the urine. Quite recently, Fichtner has called attention to a degeneration or infiltration of the epithelium of Henle’s tubes as one of the most constant of the kid- ney lesions in diabetes. In two cases of diabetic coma he found, in addition to this, very marked fatty degeneration of the cortical epithelium, the fat globules and particles being arranged along the