Volume 1

Principles and practice of medical genetics / edited by Alan E.H. Emery, David L. Rimoin ; associate editor, Jeffrey A. Sofaer ; editorial assistant, Isobel Black ; foreword by Victor A. McKusick.

Date:
1990
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Principles and practice of medical genetics / edited by Alan E.H. Emery, David L. Rimoin ; associate editor, Jeffrey A. Sofaer ; editorial assistant, Isobel Black ; foreword by Victor A. McKusick. Source: Wellcome Collection.

    34/976 (page 6)
    least in Western countries, genetic disorders contribute significantly to morbidity and mortality in childhood. Unfortunately only a relatively small proportion of individuals at risk of having a child with a serious genetic REFERENCES Boué A, Boué J 1978 Chromosome anomalies associated with fetal malformations. In: Scrimgeour J В (ed) Towards the Prevention of Fetal Malformation. Edinburgh University Press, Edinburgh, p 49-65 Carter С О 1956 Changing patterns in the causes of death at the Hospital for Sick Children. Great Ormond Street Journal 11: 65-68 Carter С О 1977 Monogenic disorders. Journal of Medical Genetics 14: 316-320 Clow C L, Fraser F C, Laberge C, Scriver C R 1973 On the application of knowledge to the patient with genetic disease. In: Steinberg A G, Bearn A G (eds) Progress in Medical Genetics. Gruñe and Stratton, New York, Vol 9, p. 159-213 Committee on Mutagenicity of Chemicals in Food 1981 Guidelines for the testing of chemicals for mutagenicity. HMSO, London Day N, Holmes L В 1973 The incidence of genetic disease in a university hospital population. American Journal of Human Genetics 25: 237-246 Edwards J H 1974 The mutation rate in man. Progress in Medical Genetics 10: 1-16 Emery A E H, Smith C 1970 Ascertainment and prevention of genetic disease. British Medical Journal 3: 636-637 Hall J G, Powers E K, Mcllvaine R T, Ean V H 1978 The frequency and familial burden of genetic disease in a paediatric hospital. American Journal of Medical Genetics 1: 416-436 McKusick V A 1988 Mendelian inheritance in man, 8th disorder are aware of this (Emery & Smith 1970, Hall et al 1978). There is therefore an important need to recognize the problem and identify those at risk of having affected children as a first step towards prevention. edn. Johns Hopkins University Press, Baltimore National Research Council 1972 Committee on the Bio logical Effects of Ionizing Radiation, Washington DC Nevin N C, Seller M J 1990 Prevention of neural-tube-defect recurrences. Lancet 1: 178-179 Reich E, Wallace S, Ben-Yishay M, Schlesinger S, Marks J, Bloom A 1974 Genetic disease in a paediatric hospital. American Journal of Human Genetics 26: 71A Roberts D F, Chavez J, Court S D M 1970 The genetic component in child mortality. Archives of Disease in Childhood 45: 33-38 Sankaranarayanan K 1988 Prevalence of genetic and parti ally genetic diseases in man and the estimation of genetic risks of exposure to ionizing radiation. American Journal of Human Genetics 42: 651-662 Shinno N W, Forsman 1, Wilson M G 1973 Genetic disorders in paediatrics. American Journal of Human Genetics 25: 70A Stevenson A C 1959 The load of hereditary defects in human populations. Radiation Research Suppl. 1: 306-321 Trimble B K, Doughty J H 1974 The amount of hereditary disease in human populations. Annals of Human Genetics 38: 199-223 United Nations Scientific Committee on the Effects of Atomic Radiation 1982 United Nations, New York United Nations Scientific Committee on the Effects of Atomic Radiation 1986 United Nations, New York World Health Organization 1986 Prevention of avoidable mutational disease. Bulletin of the WHO 64: 205-216