Interferon : principles and medical applications / editors, Samuel Baron [and others] ; associate editor, Rhonda C. Peake ; English editor, Mardelle Susman.

Galveston, TX : University of Texas Medical Branch at Galveston, Dept. of Microbiology, 1992.

xi, 624 pages : illustrations ; 23 cm

1st ed.

Includes bibliographical references and index.

Transcription of mammalian genes encoding proteins: survey of the machinery and its control -- Interferon [alpha]/[beta], gne structure and regulation -- IFN [gamma], gene structure and regulation -- Interferon inducers -- Principles of protein structure and function applicable to most proteins: aspects of protein structure, function and evolution -- Human interferon alpha family: protein structure and function -- Human interferon [beta], protein structure and function -- Gamma interferon, protein structure and function -- Structure and function of the type I interfon receptor -- IFN [gamma] receptor: protein structure and function -- Transmembrane secondary messengers for IFN [alpha]/[beta].

(cont.) Cytoplasmic events in signal transduction leading to IFN [alpha]-induced gene expression -- Interfon [gamma] signaling: current status and evidence for cross-talk with other interferons and cytokines -- Regulation of interferon-inducible genes -- MX protein: function and mechanism of action -- The 2-5 A system: 2-5 A synthetases, isospecies and functions -- The RNA-dependent P1/eIF-2[alpha] protein kinase -- Effects of interferons on mitochondria: regulation of mitochondrial gene expression -- Indoleamine 2,3-Dioxygenase -- Cell and animal effects on IFNs: natural occurrences and differentiation effects and mechanisms -- Antiviral effects of interferons: studies in animals and at the cellular level -- Mechanisms of interferons' antitumor actions.

(cont.) Interferon as a mediator of host defense against bacteria -- Anti-protozoal effects and mechanisms -- Regulation of macrophage function by interferon [gamma] -- IFN regulation of T cell function -- Interferons and the cytokine network: role in thymic and pituitary physiology, in endotoxin-induced shock and in cachexia -- The regulation of B cell function by interferon gamma -- Modulation of neutrophil functions by interferon gamma -- Introduction to clinical uses of interferons -- Biological basis for therapy and for side effects -- Pharmacokinetics of interferons and routes of administration -- Toxicity and side effects of interferons -- Interferon therapy of viral hepatitis -- Clinical use of interferons (IFNs) in respiratory and other viral diseases.

(cont.) Kaposi's sarcoma and AIDS -- Clinical use of interferons: hairy cell, chronic myelogenous and other leukemias -- Multiple myeloma and lymphomas -- Cutaneious tumors: condyloma, basal cell carcinoma, squamous cell carcinoma and melanoma -- Clinical use of interferons: solid tumors -- Interferon gamma as infection prophylaxis in chronic granulomatous disease -- Clinical use of interferons in rare hematological diseases: type-II idiopathic cryoglobulinemia and essential thrombocythemia -- Clinical use of interferons in multiple sclerosis -- Interferon research in veterinary medicine.

Copy 1. Donor: From the estate of Norman Finter.