Report of experiments now being pursued in the Bacteriological Laboratory of the Academy / by Samuel G. Dixon.

  • Dixon, Samuel Gibson, 1851-1918.
Date:
1891
Catalogue details

Licence: Public Domain Mark

Credit: Report of experiments now being pursued in the Bacteriological Laboratory of the Academy / by Samuel G. Dixon. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    degree, as is shown by a copy of the record book in a few of the cases under treatment. Rabbit D-100. Jan. 10th, 1891. Inoculated with a mass of twenty-fifth artificial cultivation of bovine tubercle bacillus. Feb. 16th, 1891. Inoculated again from the same tube as in January. Feb. 28th, 1891. Inoculated with a mass of second artificial cul- tivation of bovine tubercle bacilli. At this time the animal presents a healthy appearance and the points of inoculation have healed up. Rabbit D-101. Showed the same result as rabbit D-100 Without going into further detail, [ will simply state that a num- ber of guinea pigs have given like results; whereas the animals in- oculated with a mass of the second cultivation of bovine tubercle bacilli, not having been previously inoculated with the attenuated virus, sickened with tuberculosis and in some instances died. The last experiments confirm the fact that the tubercle bacillus does lose its virulence to a certain degree by cultivating it con- tinuously on an artificial medium. Dog C-l. Eight weeks old, weight l* lbs. Was inoculated with second artificial-culture of bovine tubercle bacillus and died within ten days, of toxaemia. Dog C-2. Same age and weight as C-l. Under the same treat- ment, also sickened with tuberculosis. Dog C-3. Same age and weight as C-l. Was at the same time inoculated with twenty-fifth artificial culture of bovine tubercle bacillus. While the others sickened with tuberculosis, this one shows no outward manifestation of the malady. In one of my recent communications, I referred to the fact that I had been injecting predigested fat plus antiseptics into the intestinal tract of animals suffering from tuberculosis with some success and also that I was subcutaneously introducing some of the bile salts. The results from the bile salts have not been at all constant; while the subcutaneous injection of glycerine into the tuberculous animals, which I recently referred to in a Medical Journal of this city, has apparently given a result which will stimulate work in this direction. Two dogs eight weeks old had respectively a mass of the second cultivation of bovine tubercle bacilli subcutaneously introduced. In seven days one was dead apparently from the toxic effect of the product of the bacilli.