On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc.

  • Hunter, Walter King.
Date:
[1897?]
Catalogue details

Licence: Public Domain Mark

Credit: On the pathology of pernicious anaemia / by Walter K. Hunter, M.D., B.Sc. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    ferrocyanide and hydrochloric acid, so as to demonstrate any deposit of iron pigment that might exist. In the liver this deposit was considerable, both in the capillaries and in the liver cells. In the capillaries it appeared as small dark blue masses and in the hepatic cells in a much finer state of division. This pigment was most abundant in the cells at the outer parts of the lobules. In the spleen only a very few cells contained pigment, and the same applied to the epithelium of the kidneys. In the bone marrow there was a moderate de- posit of iron, but it was impossible to state in what cells it was contained. Case 2. Mrs. S., act. 30. Died Feb. 2, 1895. A history of gradually increasing weakness, pallor, emaciation, vomiting, diarrhoea. Duration of illness about one year. Urine contained a trace of albumin. Blood, (a) a month before death—red cor- puscles 3 0 per cent., haemoglobin 3 5 per cent.; (b) a day before death—red corpuscles 16’3 per cent., haemoglobin 17 per cent. Post-mortem examination.—Pericardium contained 3 \ ozs. clear serum. Heart (11£ ozs.) had no external fat, muscle presented no appearance of fatty degeneration. Lungs, emphy- sematous and oedematous. Liver (49 ozs.) presented no fatty change. Spleen (3f ozs.) normal. Left kidney markedly cirrhosed, right kidney showed commencing cirrhosis. Supra- renal capsules normal. Mesenteric glands slightly enlarged. No specimen of bone marrow. Deposit of iron pigment in the liver cells was very marked Present also to a slight degree in the capillaries. No iron pigment in the other organs. Case 3.1 M. T., act 52. Died May 7, 1892. Symp- toms were progressive weakness, pallor, palpitation, breathless- ness, oedema of feet, frequent attacks of vomiting. No albumin in urine, no history of haemorrhages. Duration of illness about two years. Red corpuscles 10 per cent., haemoglobin “ showed a marked reduction.” Post-mortem examination.—Heart (16 ozs.) healthy except for a pretty considerable fatty degeneration of its muscle fibre. 1 This case was reported by Dr. Gemmell and Dr. Steven at a meeting of the Glasgow Pathological and Clinical Society, May 9, 1S92. (See Gtas. Med. Jour., October, 1892.)