Understanding depression : a translational approach / edited by Carmine M. Pariante, Randolph M. Nesse, David Nutt, Lewis Wolpert.

Date:
2009
  • Books

About this work

Description

Depression is a major cause of morbidity throughout the world. Given that between 8 and 12% of the population (in most countries) will suffer from depression at some point in their lives, it is clearly a significant public health problem. As our knowledge of this illness has expanded in recent years, it has become clear that depression can no longer be viewed as a simple disorder of the brain. It has to be seen as a series of behavioural and biological changes that span mind, brain, genes, and body--indeed, affecting both psychological and physical health. This book brings together world leaders in research on depression to discuss, for the first time, in an interdisciplinary setting, both classical and innovative ideas to understand this devastating disorder. It presents neurobiological, psyschological, genetic, and evolutionary models with a particular emphasis on the mechanisms linking the brain to the endocrine and the immune systems, and therefore, linking depression to physical health. Opening with a powerful, personal account of depression that conveys something of the all-consuming, debilitating nature of this illness, the book then presents cutting-edge research from those at the frontier of work in this area.

Publication/Creation

London ; New York : Oxford University Press, 2009.

Physical description

xii, 385 pages : illustrations ; 25 cm

Bibliographic information

Includes bibliographical references and index.

Contents

Experiencing depression / Lewis Wolpert -- Depression in the medically ill / Monica Kelly Cowles, Carmine Pariante & Charles B Nemeroff -- Explaining depression: neuroscience is not enough, evolution is essential / Randolph M Nesse -- Evolutionary genetics of affective disorders / Bernard J Crespi -- Genetic factors in stress and major depression / Stephan Claes, Elisabeth B Binder & Charles B Nemeroff -- Bipolar disorder and unipolar depression: what is the genetic relationship? / Daniel J Smith, Michael J Owen & Nick Craddock -- The significance of dysregulated basal glucocorticoid pulsatility in affective disorders / Becky Conway-Campbell, C C Wiles & Stafford Lightman -- Early life programming of affective function / Caitlin S Wyrwoll, Megan C Holmes & Jonathan R Seckl -- Modeling depression by GR mutant animals? / Sabine Chourbaji & Peter Gass -- Cytokines and depression: experimental evidence and intermediate mechanisms / Robert Dantzer, Jason C O'Connor, Nathalie Castanon, Jacques Lestage & Keith W Kelley -- Do depression, stress, sleep disruption and inflammation alter hippocampal apoptosis and neurogenesis? / Paul Lucassen, Peter Meerlo, A S Naylor, A M van Dam, A G Dayer, B Czeh & C A Oomen -- The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events / Steven F Maier, Jose Amat, Michael V Baratta, Sondra T Bland, John C Christianson, Brittany Thompson, Robert R Rozeske & Linda R Watkins -- Is it all monoamines? / Philip J Cowen & C J Harmer -- The role of affective processing in vulnerability to and resilience against depression / Nicole Geschwind, Jim van Os, Frenk Peeters & Marieke Wichers -- PTSD and HPA axis: same hormones, different disorders / Elizabeth Young -- Neuroendocrine and immune cross talk in major depression / Timothy G Dinan & Peter Fitzgerald -- Neuropsychiatric effects of IFN-alpha: relevance to depression / Andrew H Miller, Thaddeus W W Pace & Charles I Raison -- Depression and coronary heart disease / Andrew Steptoe -- Does depression induce pain and fatigue? / Tony Cleare -- Explaining the association between depression and mortality: a life course epidemiology approach / Matthew Hotopf & Max Henderson -- Depression: unipolar or bipolar, what's the difference (and what does it matter anyway)? / Allan H Young -- Can neuroimaging help distinguish bipolar depression from major depressive disorder? / Matthew T Keener & Mary L Phillips -- Pharmacogenetics of antidepressant response / Bhanu Gupta, Robert Keers, Rudolf Uher, Peter McGuffin & Katherine J Aitchison -- Can the EEG be used to predict antidepressant response? / R Hamish McAllister-Williams & Grzegorz Wisniewski -- Can we use magnetic/electric fields to help in treatment resistant depression? / Thomas E Schlaepfer & Bettina Bewernick -- Antiglucocorticoids in the treatment of affective disorders: from pre-clinical to clinical studies / Sarah E Gartside, K S Reid & I Nicol Ferrier -- How can we use current knowledge to improve antidepressant treatments? / David Nutt & Christoher A Lowry.

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Where to find it

  • LocationStatus
    Medical Collection
    WM171 2009U55
    Open shelves

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Identifiers

ISBN

  • 9780199533077
  • 0199533075