Subcellular fractionation : liver lysosomes and iron overload.

London : University of London Audio-Visual Centre, 1975.

1 encoded moving image (26.22 min.) : sound, black and white.

00:26:20

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr T J Peters, Royal Postgraduate Medical School. Produced by David R Clark. Made for British Postgraduate Federation. Made by University of London Audio-Visual Centre.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Peters introduces the lecture. He shows electron micrographs and refers to diagrams and describes the appearance and function of a liver cell, a hepatocyte. Time start: 00:00:00:00 Time end: 00:06:01:00 Length: 00:06:01:00

Segment 2 A short film of a zonal rotor at work is shown. Peters explains in detail how it works. Time start: 00:06:01:00 Time end: 00:10:02:00 Length: 00:04:01:00

Segment 3 The short film of the zonal rotor continues to play. Time start: 00:10:02:00 Time end: 00:15:10:00 Length: 00:05:08:00

Segment 4 Peters describes the technique of microanalytical subcellular fractionation and talks about how it is applicable to several different areas of clinical medicine including the study of cardiac and intestinal tissues. Time start: 00:15:10:00 Time end: 00:21:11:00 Length: 00:06:01:00

Segment 5 Peters concludes with a discussion on how accumulated iron damages the lysosome and he assesses the evidence for and against this. Time start: 00:21:11:00 Time end: 00:06:01:00 Length: 00:06:11:13