Treatment of bacterial diseases / [Sheridan Delépine].

  • Delépine, Sheridan, 1855-1921.
Date:
[1891?]
Catalogue details

Licence: Public Domain Mark

Credit: Treatment of bacterial diseases / [Sheridan Delépine]. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    other febrile aflfections previously established. Daniellsen and Boeck were perhaps the first to notice this fact, and to record the beneficial influence which an attack of small- pox might have on the course of tubercular leprosy. I need not refer to the numerous attempts which have been made since in that line. 3. Refractory state produced by inocidation of a virus modified by cultivation outside the body.—Another discovery, more fertile in results, although similar in principle, was, however, made known by Pasteur in 1880. He showed that by cultivating the microbe causing chicken cholera at a temperature of 33°, with free access of oxygen, he could obtain in from two to eight months an attenuated virus, which would cause the disease in a form mild, but sufficient to produce immunity. Toussaint and Chauveau were ex- perimenting at the same time on the anthrax bacillus. Tous- saint made the important discovery that by heating cultiva- tions of the bacillus anthracis rapidly to a comparatively high temperature its virulence was attenuated. In 1881 Pasteur produced attenuation of virulence of the bacillus anthracis by cultivation for nine days at a temperature of from 42° to 43° C, and produced immunity by vaccination with the modified virus. Koch, Gaff-ky, and Loeffler repeated Pasteur's experiment in 1884, confirmed his results, and extended them, diff-ering from him only with regard to the influence which he attributed to oxygen. In 1882 Pasteur and Thuillier applied to the bacillus of«' rouget the same principle as that used in the case of the chicken cholera and splenicfever,and succeeded in attenuating that virus also Daring the whole of this period Pasteur was occupied in trying to isolate the virus of rabies. Although he did not succeed in doing so, he discovered that the nervous tissues acquired in that disease virulent properties which indicated the presence