Alternatives to animal testing : new ways in the biomedical sciences, trends and progress / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT.

Weinheim ; New York : VCH, [1994], ©1994.

xviii, 182 pages : illustrations ; 24 cm

Papers from a symposium held at the ETH, Zurich on Nov. 30, 1992, and updated to include developments through fall 1993

Includes bibliographical references and index

Looking back 33 years to Russell and Burch: the development of the concept of the threes Rs (alternatives) / A.N. Rowan -- OECD and international regulatory acceptance of the three Rs / H.M. Van Looy, H.B.W.M. Koeter -- European Centre for the Validation of Alternative Methods (ECVAM) / E. Marafante, M. Balls -- Timetable for replacing, reducing and refining animal use with the help of in vitro tests: the limulus amebocyte lysate test (LAL) as an example / O. Flint -- Fund for the replacement of animals in medical experiments (FRAME): 23 years of campaigning for the three Rs / M. Balls, J.H. Fentem -- Animal use and alternatives: developments in the Netherlands / L.F.M. van Zutphen -- RIVM Center for Alternatives to Animal Testing and the concept of the three Rs in the quality control of vaccines / C.F.M. Hendriksen -- ZEBET: three years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin / H. Spielmann, G. Grune-Wolff, M. Liebsch

(cont) Reviewed literature databank for alternatives to animal experiments-"Gelve Liste" / B. Rusche, U.G. Sauer -- SIAT research, teaching and consulting program in the area of vitro toxicology. Experimental research, screening and validation / C.A. Reinhardt -- Computer-aided drug design and the three Rs / A. Vedani -- Computer-aided programs in biomedical education / R.T. Fosse -- Alternatives to experiments with animals in medical education: a TEMPUS joint European project / M. Cervinka ... [et al.] -- Replacement of laboratory animals in the management of blood-sucking arthropods / A.E. Issmer ... [et al.] -- Maintenance of filarial cycles in the laboratory: approaches to replacing the vertebrate host / J. Rapp ... [et al.] -- Improved drug metabolizing capacity of hepatocytes co-cultured with epithelial cells and maintained in a perifusion system / R. Gebhardt -- Characterization and use of long-term liver cultures to evaluate the toxicity of cyclophosphamide or benzene to bone marrow cultures / B.A. Naughton ... [et al.]

(cont) European interlaboratory evaluation of an in vitro ocular irritation model (Skin2TM model ZK1100) using 18 chemicals and formulated products / P.W. Joller ... [et al.] -- Cellular assays for testing peritoneal dialysis bags / M. Dawson, Z. Jabar -- Position of the authorities / L. Pioda.