Vitamin A as an anti-infective agent / by H.N. Green and E. Mellanby.

  • Green, H. N. (Harry Norman)
Date:
[1928?]
Catalogue details

Licence: In copyright

Credit: Vitamin A as an anti-infective agent / by H.N. Green and E. Mellanby. Source: Wellcome Collection.

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    the right Fallopian tube and bladder. Intestine acutely inflamed and contains blood-stained serum. Right side of pelvic floor inflamed, being a mass of necrosed friable tissue with an abscess cavity extending down to bone. Fallopian tubes show small white areas (similar to those seen in the kidneys, and probably necrotic) scattered on the outer surface. Right tube inflamed and adherent to the pelvic floor and intestine. Spleen enlarged. This rat had haematuria prior to death. Rat 287.—Stomach full of blood. Pyloric mucosa injected and showing haemorrhage into it. Left kidney slightly enlarged with semipurulent fluid in pelvis. Left ureter dilated. A large number of small stones and much epithelial debris at base of bladder. Two sessile red projections springing from bladder mucosa (granulomata or papillomata). Very large abscess in right sub¬ maxillary gland extending to level of first rib and upwards to the mandible. Chain of enlarged longitudinal glands on left side, some commencing to suppurate. Small abscess in either thyroid. Pus from abscess shows in film numerous Gram-positive diplococci, Gram-negative bacilli, and a few staphylococci and streptococci. Rat Jf21.—Large abscess of tongue extending almost to the tip and communicating with another large abscess underlying the left mandible. The tongue abscess has perforated and there is pus in the larynx. Stomach full of altered blood; mucosa injected with numerous streaky haemorrhages; petechial haemorrhages on outer surface of cardiac portion, and cardiac epithelium shows a curious circumscribed rugosity at the upper pole. Bladder small and full of a bright yellow sandy deposit (showing chiefly calcium oxalate crystals). Spleen shows on its surface numerous circular white foci (similar to those often seen in the kidney). Right epididymis intensely inflamed. Rat 288.—Severe enteritis (chiefly of jejunum). Small amount of altered blood in stomach. Pelvis of left kidney much dilated. Left ureter enormously dilated, the distal end being inflamed and filled with the same type of necrotic material as is found in the bladder. Right ureter moderately dilated. Bladder grossly inflamed; mucosa covered with shaggy masses of granulation tissue and necrosed cells which are very adherent, whilst papillomatous-like masses are numerous. Abscess at base of tongue has perforated and formed an abscess in the mid-line of neck overlying the larynx, and communicates with an external sinus. Left seminal vesicle enlarged and appears caseous. Abscess in left prostate. Nasal sinuses full of pus. III.—Control Animals—Basal Diet-{-Vitamin D (Irradiated Ergosterol) + Borne Source of Vitamin A (Dried Cabbage or Butter or Cod-liver Oil). Fifty rats of the same age and weight were kept for longer periods than the foregoing on diets which, while made up in the same way as those of the other experimental animals, contained some source of vitamin A, generally dried cabbage, but in some cases butter or cod-liver oil. No gross infective lesion was found in any of these animals, the only pathological findings discovered being three cases of hepatic cyst of parasitic origin. Discussion of Results. The fact that in practically all of the rats on a vitamin A deficient diet upon which a detailed post-mortem examination has been made some and generally many organs have been found to be infected by micro-organisms,