Prostaglandins. Parts 1 & 2.

UK : University of London, 1971.

1 encoded moving image (54.52 min.) : sound, black and white.

00:54:52

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Professor E W Horton, Department of Pharmacology, University of Edinburgh. Introduced by Dr Ian Gilliland. Produced by Peter Bowen. Made for British Postgraduate Medical Federation. made by University of London Audio-Visual Centre, 1971.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Dr Ian Gilliland introduces Professor E W Horton. Horton, seated, talks to camera. He describes how prostaglandins were discovered in the 1930s, then isolated in 1960. He shows a diagram detailing the four main groups of prostaglandins. Referring to further diagrams, Horton shows how the four prostaglandins differ in their biological activities. Time start: 00:00:00:00 Time end: 00:05:57:22 Length: 00:05:57:22

Segment 2 Horton describes the biological function of specific prostaglandins, writing on a chalk board to illustrate his points. He then refers to a diagram which details which parts of the body each prostaglandin type is most likely to be found in. Time start: 00:05:57:22 Time end: 00:10:44:00 Length: 00:04:46:03

Segment 3 Horton shows diagrams which compare the molecules of different prostaglandins. He then refers to experiments in which prostaglandins have been injected into animals. Autoradiographs are shown which detail the results of the experiments. Time start: 00:10:44:00 Time end: 00:16:15:19 Length: 00:05:31:19

Segment 4 Horton talks about the extraction and estimation of prostaglandins. He shows examples of different methods of separating prostaglandins from tissue culture samples. Then, using diagrams, he describes various methods of how to identify different prostaglandins from the tissue samples. Time start: 00:16:15:19 Time end: 00:20:27:22 Length: 00:04:12:03

Segment 5 Horton describes how the molecular mass of prostaglandins can be calculated. Time start: 00:20:27:22 Time end: 00:24:42:22 Length: 00:04:15:00

Segment 6 Horton completes his discussion of methods for estimating prostaglandin levels, then introduces Part Two. Opening credits and titles of Part Two. Time start: 00:24:42:22 Time end: 00:28:20:22 Length: 00:03:38:00

Segment 7 Horton introduces the subject of the pharmacological actions of prostaglandins. He shows four photographs of chicks at various stages of an experiment to inject them with prostaglandins. Graphs and diagrams are used to display the results of the experiment. Time start: 00:28:20:22 Time end: 00:35:53:11 Length: 00:07:32:14

Segment 8 Horton discusses the effects of oestrogen treatments on prostaglandin levels in different animals including guinea pigs and sheep. He presents the results of these experiments by drawing diagrams on a chalk board. Time start: 00:35:53:11 Time end: 00:39:29:19 Length: 00:03:36:08

Segment 9 Horton continues to discuss the effects of different prostaglandins on different animals. He outlines which bodily functions suppress prostaglandin action and which promote it. Time start: 00:39:29:19 Time end: 00:44:53:05 Length: 00:05:23:11

Segment 10 Horton differentiates further between different types of prostaglandin, detailing which types of hormones have the most powerful effect on prostaglandin levels. He uses a chalk board to write various diagrams and equations on. Time start: 00:44:53:05 Time end: 00:49:56:00 Length: 00:05:02:20

Segment 11 Horton sums up the lecture and discusses some final issues about the effects of prostaglandins on the body. Time start: 00:49:56:00 Time end: 00:54:52:21 Length: 00:04:56:21