HLA and malignancy : proceedings of a symposium presented by Roswell Park Memorial Institute, Buffalo, New York, August 19-20, 1976 / editor in chief: Gerald P. Murphy; associate editors: Elias Cohen, John E. Fitzpatrick, David Pressman.

Date:
1977
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Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: HLA and malignancy : proceedings of a symposium presented by Roswell Park Memorial Institute, Buffalo, New York, August 19-20, 1976 / editor in chief: Gerald P. Murphy; associate editors: Elias Cohen, John E. Fitzpatrick, David Pressman. Source: Wellcome Collection.

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    Ordering of Genes for HLA Antigens and Complement Components on tlie Human 6th Chromosome C. B. Carpenter, D. Raum, D. Glass, and P. H. Schur HISTOCOMPATIBILITY LOCI Closely linked genes of central importance in tissue transplantation exist in all species studied so far. Early work in the mouse with tumor transplantation demonstrated the presence of a strong transplantation antigen system determined by a chromosomal region, called H-2. This H-2 region has been resolved into a number of closely Unked genes, some of which determine serologically defined (SD) antigens [27], while others determine immune-responsiveness (Ir) to certain antigens [5], and to the recognition and response to lymphocyte- activating determinants (LD) in vitro [54, 55]. The human MHC is now called HLA [66], and this region has been shown by family studies and somatic cell hybridization experiments to be on the 6th chromosome [30, 25]. In recent months there has been very rapid progress in the definition of the fine structure of the HLA region, both in terms of the loci related to transplantation allo- immunity and to the mapping of genes for certain complement components. HLA serologically defined antigens are usually detected by alloantibodies re¬ acting with lymphocytes in a lymphocytotoxic (complement-dependent) reaction. These classical HLA antigens are present on the surface of all nucleated cells, and are known to be glycoproteins, each consisting of a heavy and a light chain. The specificities of the 3 SD loci (A, B, C) consist of j32-microglobulin as the light chain, while the heavy chain contains the variable conformation unique to the antigen specificity [58, 47, 56, 43]. Certain structural homologies exist among the heavy chains of the antigens of the 3 loci, lending weight to the hypothesis 9 HLA and Malignancy, pages 9—20 © 1977 Alan R. Liss, Inc., New York, N.Y.